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Rafael Bermeo thesis defense on June, 18th 2021

Rafael Bermeo will defend his thesis on June 18th, 2021, which he performed under the supervision of Dr. Annabelle Barrot (CNRS Research Director at Cermav - UPR5301) and which is entitled “Design, synthesis and evaluation of antagonists towards BC2L-C ”. Click on the title for more information.

Fur4Sustain training school on ‘Polymer Characterization’

341 / 5000 Résultats de traduction We are pleased to announce the first FUR4Sustain training school on “Characterization of polymers” with the intervention of Dr Laurent Heux and Jean-Luc Putaux. The event will be held at the Université Côte d'Azur in Nice (FR) from June 14 to 17 (face-to-face or virtual via zoom). Click on the title for more information.

Lukáš Gajdoš thesis defense on May, 20th 2021

Lukáš Gajdoš from Cermav-UPR5301 and Institut Laue-Langevin in Grenoble will defend his thesis entitled: “Neutron diffraction for deciphering lectin-glycan interactions involved in bacterial infection”. Click on the title for more information.

Visualisation of hydrogen atoms in a perdeuterated lectin-fucose complex reveals key details of protein-carbohydrate interactions

The pathogenic bacteria attach themselves to the cells which they attack thanks to the sugars present on their membrane. A crucial mechanism to study, because it would help to treat these infections without reinforcing the resistance of the bacteria. To do this, researchers from CERMAV (CNRS), the Laue-Langevin Institute (ILL) and CEITEC (Masaryk University, Czech Republic) have modified a sugar so that it responds to neutron crystallography, a technique that reveals how bacteria cling to sugars. This work, published in the journal Structure, could extend to more complex sugars to better understand different biological phenomena and propose new anti-infectious strategies. Caption: Fucose molecule in the lectin binding site. The blue grid represents the density determined by x-rays and the green grid the density determined by the neutrons around the fucose and the amino acids of the lectin. Hydrogen atoms (here isotope deuterium) are represented by yellow balls. The continuity of the green grid between the fucose and the amino acids allows a direct view of the hydrogen bonds. © L. Gajdos. / Click on the title for more information.
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