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Self-Assembly of Glycopolymers

The A2G team's expertise focuses on the preparation of glycoconjugates or glycopolymers with a variety of architectures using direct and selective chemistry, for the study of their self-assembly in solution (glyco-nanoparticles, supramolecular hydrogels) or in the solid state (nanostructured thin glyco-films, electrospun glyco-fibers) with various applications: (Bio)nanoelectronics, Biomedical, Cosmetics, Biosensors, Selective filtration,... .

Green glycochemistry

To obtain these new smart biomaterials, eco-friendly chemistry is most often used, following the main principles of green chemistry.  Starting with biosourced carbohydrates, direct and selective functionalization is favored to obtain building blocks capable of self-assembly in solution or as thin films.

New and existing methodologies are used and improved, enabling fast, efficient and scalable access to glycopolymers (block copolymers, glycoamphiphiles, glycoconjugates, polysaccharide derivatives).

Controlling glycopolymer self-assembly

The team has built up relevant expertise in the molecular design of carbohydrates to control their self-assembly properties in solution or as thin films. We have developed shaping processes to obtain glycostructures of various sizes and morphologies.

  • Glyco-nanoparticles for encapsulating active or functional agents (drugs, colorants, fragrances, (bio)catalysts, etc.).
  • Glyco-nanostructured thin films for (bio)nanoelectronics (nanolithography, OLEDs, transistor memories, photovoltaics, etc.).
  • Supramolecular glyco-gels for matrix therapy, disease treatment and fat phase texturing (cosmetics, lubricants, food, dermopharmaceuticals, etc.).
  • Electrospun glyco-fibers for stimuli-sensitive actuators, selective filtration membranes, etc.

These glycostructures are studied using tools applied to soft matter (radiation scattering, imaging techniques, etc.) such as elastic and quasi-elastic light scattering, small-angle X-ray scattering and electron microscopy (TEM, cryo-TEM, SEM and AFM).

Recent research contracts

  • Efficient chiral separation using electrospun cellulose membranes (ANR PRC -ChiralCell 2023-2027)
  •  New structural color biomaterials from self-assembly of biobased brush copolymers (ANR PRC – SugarColors 2023-2027)
  • Laboratoire International France-Taiwan CNRS-UGA-NTU in Taipei – Green Material Institute (2021-2025)
  • Stealth carbohydrates as antibacterial agents (EUR-CBH 2023-2026)
  • Carbohydrate Block Copolymers for stretchable transistor memory devices (IDEX IRGA GLYCO_TRANSISTOR 2021-2024)

The A2G team (november 2023)

Permanent staff

Non permanent staff

  • Hong LI, Post-doc fellow
  • Steve NONO-TAGNE, Ph.D. student
  • Aïcha ABDALLAH, Ph.D. student
  • Bing CHEN, Ph.D. student
  • Ping-Jui YU, Ph.D. student  (co-supervision NTU)
  • Dorcas OVUREVU, Ph.D. student (co-supervision LRP)
  • Bastian BOHRER, Ph.D. student
  • Chun Chieh HO, Ph.D. student (co-supervision  NTU)