UPR 5301

Centre de recherches sur les macromolécules végétales

Wei Li thesis defense on July, 26th 2021

This thesis was completed in our laboratory, under the supervision of Dr. Yoshiharu NISHIYAMA. The subject is: "Preparation of cellulose oligomers by acid hydrolysis." Click on the title for more information.

Computational Modeling in Glycoscience

Advancements in high-performance computing have allowed molecular simulation methods to play a more substantial role in supporting experiments and transcend such mandate to guide experimental design and lead autonomously scientific discovery. This review presents the foundations underlying the multiscale molecular simulations methods, from atomistic to coarse-grained, used in complex carbohydrate research. The applications to glycan and glycoconjugates, polysaccharides, proteins-glycans interactions,… illustrate the relevance of computer simulations to the field of glycoscience. Click on the title for more information.

Electrospun Cellulosic Membranes toward Efficient Chiral Resolutions via Enantioselective Permeation

Many biologically-active compounds, such as drugs, agrochemicals, food additives, etc. have chiral structures (like right- and left-hands) and their physiological properties usually depend on their chirality. In this study, cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC), known as one of the most versatile chiral selectors packed in columns for chiral chromatography, is electrospun for the first time to fabricate an enantioselective membrane toward efficient chiral resolutions. We believe that such a novel electrospun cellulosic membrane having both the enantioselective permeation property and the capacity to be used in pressure-driven filtration processes is a significant step forward toward large-scale chiral resolutions. Click on the title for more information.

Electrospun Polysaccharidic Textiles for Biomedical Applications

We are publishing a new review on electrospun polysaccharide textiles for biomedical applications, in a new open access journal entitled Textiles, which covers studies in the field of textile science and industry. Click on the title for more information.

Proteome-wide prediction of bacterial carbohydrate-bindingproteins as a tool for understanding commensal and pathogencolonisation of the vaginal microbiome

Bacteria use carbohydrate binding proteins (CBP), such as lectins and carbohydrate binding modules (CBMs), to anchor themselves to specific sugars on host surfaces. This study provides new insight into the potential mechanisms of colonization by commensals and potential reproductive tract pathogens that underlie health and disease states. Click on the title for more information.

Juliette Francillon thesis defense on June 25th, 2021

Juliette Francillon completed her thesis in co-supervision between our laboratory, under the direction of Dr. Claire Boisset, and the laboratory Papermaking Process Engineering Laboratory (LGP2) - UMR CNRS 5518 - Grenoble INP - Agefpi in Grenoble, under the direction of Prof. Christine Chirat. Her thesis is entitled: "Study of the molecular diversity of soluble hemicellulose oligosaccharides derived from wood autohydrolysates."