The evolutionary advantage of an aromatic clamp in plant family 3 glycoside exo-hydrolases
A study combining mutagenesis experiments, high-resolution X-ray diffraction with thiosugars and molecular modeling has revealed the molecular basis for the specificity and processivity of an enzyme of the GH3 family of glycoside hydrolases.
Interview with Anne Imberty in Le Monde Science
Anne Imberty, CNRS Research Director at Cermav, was interviewed in Le Monde Sciences about Glycosciences.
Simon Coninx thesis defense on October 24th, 2022
Simon Coninx completed his thesis at Cermav under the supervision of Rachel Auzely, Professor at Université Grenoble Alpes. It is entitled “Nanogels based on boron-rich glycosaminoglycans for the multi-modal treatment of cancer”. Click on the title for more information.
The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3
Choanoflagellate lectin SaroL-1 binds to cancer-related α-galactosylated epitopes and can be toxic to cancer cells through a pore-formation mechanism. Click on the title for more information.
Press article on the Carbogel project led by Sami Halila
The Carbogels project led to patent application for a new class of organogelator with adjustable rheological properties for cosmetics and dermopharmacy. Click on the title for more information.
Multifaceted Computational Modeling In Glycoscience
This review comprehensively presents all the numerical simulation methods to cover the different levels of structural organization of complex glycans and polysaccharides and the range of their interactions with proteins. Click on the title for more information.
Eleventh Erwin Felix Lewy Bertaut Prize to Dr. Lukáš Gajdos
Lukáš Gajdos completed his thesis at Cermav under the co-direction of Anne Imberty (CNRS Research Director) and the Laue-Langevin Institute in Grenoble, France. Click on the title for more information.
Dylan Jabeguero thesis defense on June 30th, 2022
Dylan Jabeguero completed his thesis at Cermav under the supervision of Christelle BRETON (Professor at University Grenoble Alpes). It is entitled “Engineering and applications of glycosyltransferases for synthetic glycobiology: Two galactosyltransferases, MGD1 and LgtC, as case studies”. Click on the title for more information.
Simona Notova thesis defense on June 29th, 2022
Simona Notova completed her thesis at Cermav under the supervision of Anne Imberty (CNRS Research Director). It is entitled “Engineering of neo-lectins and Janus lectins”. Click on the title for more information.
Publication of the book “Essential Glyocobioloy fourth edition” (available free of charge)
Cermav participated in the writing of 3 articles of this book which is considered as the bible of glycobiologists. Click on the title for more information.
The Cosmetic Research Tour stops in Grenoble on April 29, 2022
Organized by The Cosmetic Valley, the University of Grenoble Alpes and the CNRS, the Cosmetic Research Tour aims to boost public/private collaboration for cosmetics. Click on the title for more information.
Redouane Borsali is appointed/elected member of the European Academy of Sciences – Engineering Division
The European Academy of Sciences (EURASC) is an independent, non-profit, non-governmental organization. It brings together the most eminent scholars and engineers carrying out cutting-edge research and the development of cutting-edge technologies. One of its objectives is to promote fundamental research and excellence in science and technology. Click on the title for more information.
Maeva Touzard thesis defense on May 24th, 2022
Maeva Touzard completed her thesis at Cermav under the supervision of Laurent Heux (CNRS Research Director). It is entitled “Biomimetic materials of the plant cell wall and enzymatic modifications”. Click on the title for more information.
The 2020 Catalán-Sabatier Award for Anne Imberty
After postponements due to the pandemic, Anne Imberty was able to receive the 2020 Catalán-Sabatier Award. Click on the site to access the content.
Publication of our activity brochure
Cermav publishes its activity brochure focused on recent scientific activities and events from 2017 to 2021. Click on the title to access it.
Sami Halila wins The Cosmetic Victories Academic Award!
The Carbogels project is managed by Sami Halila (CNRS researcher) at Cermav, and led to patent application for a new class of organogelator with adjustable rheological properties for cosmetics and dermopharmacy. Click on the title for more information.
Topological defects in polycrystalline hexosomes from β-cyclodextrin fatty esters
Dislocations and tilt grain boundaries have been observed in colloidal polycrystalline hexosomes of amphiphilic β‑cyclodextrins acylated with C14 chains, and described using the concepts of coincidence site lattice and structural units. Click on the title for more information.
Crystal and molecular structure of V-amylose complexed with butan-1-ol
By combining a systematic approach of energy relaxation and molecular modeling with structural refinement from diffraction data, we have determined the molecular and crystal structure of the complex of amylose with butan-1-ol, validating the geometrical model proposed by William Helbert and Henri Chanzy in 1994. Click on the title for more information.
Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding
Lukas Gajdos et al., Nature communications 2022. Click on the title for more information.
Size-controlled synthesis of beta(1–>4)-GlcNAc oligosaccharides using an endo-glycosynthase.
An enzymatic cascade using a new glycosynthase derived from a lysozyme was developed by the CBO team in order to prepare long-chain chitin oligosaccharides with perfect control over their size and excellent yields. Click on the title for more information.
A New Route to NAG-NAM Disaccharide, an Important Building Block for Peptidoglycan Oligomer Synthesis.
The Chemistry and Biotechnology team of CERMAV has just published a very efficient methodological approach for the synthesis of the repeating unit of peptidoglycan, an essential constituent of the bacterial cell wall whose biosynthesis is targeted by most antibiotics.
This first result is the basis of a global strategy for accessing synthetic peptidoglycan oligomers, fundamental tools to decipher the life cycle of this complex polymer.
Click on the title for more information.
Kanhaya Lal thesis defense on December 15th , 2021
Kanhaya LAL is defending his thesis at CERMAV in the framework of the European project PhD4GlycoDrug, in co-tutorship with the University of Milan. It is entitled “Structure-based design of Glycomimetic ligands for the N-Terminal domain of BC2L-C Lectin”.
Antoine Rousseau thesis defense on December 16th , 2021
Antoine Rousseau completed his thesis at Cermav under the co-supervision of Sébastien Fort (CNRS Research Director) and Sylvie Armand (Lecturers at Université Grenoble Alpes). It is entitled “Peptidoglycan oligomers synthesis to study the bacterial cell wall metabolism”. Click on the title for more information.
Video : Hamed Ahmadi-Nohadi research work
Discover the manufacture of micro / nanofiber layers by the electrospinning method developed in Hamed Ahmadi-Nohadi’s thesis under the supervision of Issei Otsuka, thanks to funding from Labex Arcane.
Click on the title to access the video.
