The Cosmetic Research Tour stops in Grenoble on April 29, 2022
Organized by The Cosmetic Valley, the University of Grenoble Alpes and the CNRS, the Cosmetic Research Tour aims to boost public/private collaboration for cosmetics. Click on the title for more information.
Redouane Borsali is appointed/elected member of the European Academy of Sciences – Engineering Division
The European Academy of Sciences (EURASC) is an independent, non-profit, non-governmental organization. It brings together the most eminent scholars and engineers carrying out cutting-edge research and the development of cutting-edge technologies. One of its objectives is to promote fundamental research and excellence in science and technology. Click on the title for more information.
Maeva Touzard thesis defense on May 24th, 2022
Maeva Touzard completed her thesis at Cermav under the supervision of Laurent Heux (CNRS Research Director). It is entitled “Biomimetic materials of the plant cell wall and enzymatic modifications”. Click on the title for more information.
The 2020 Catalán-Sabatier Award for Anne Imberty
After postponements due to the pandemic, Anne Imberty was able to receive the 2020 Catalán-Sabatier Award. Click on the site to access the content.
Publication of our activity brochure
Cermav publishes its activity brochure focused on recent scientific activities and events from 2017 to 2021. Click on the title to access it.
Sami Halila wins The Cosmetic Victories Academic Award!
The Carbogels project is managed by Sami Halila (CNRS researcher) at Cermav, and led to patent application for a new class of organogelator with adjustable rheological properties for cosmetics and dermopharmacy. Click on the title for more information.
Topological defects in polycrystalline hexosomes from β-cyclodextrin fatty esters
Dislocations and tilt grain boundaries have been observed in colloidal polycrystalline hexosomes of amphiphilic β‑cyclodextrins acylated with C14 chains, and described using the concepts of coincidence site lattice and structural units. Click on the title for more information.
Crystal and molecular structure of V-amylose complexed with butan-1-ol
By combining a systematic approach of energy relaxation and molecular modeling with structural refinement from diffraction data, we have determined the molecular and crystal structure of the complex of amylose with butan-1-ol, validating the geometrical model proposed by William Helbert and Henri Chanzy in 1994. Click on the title for more information.
Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding
Lukas Gajdos et al., Nature communications 2022. Click on the title for more information.
Size-controlled synthesis of beta(1–>4)-GlcNAc oligosaccharides using an endo-glycosynthase.
An enzymatic cascade using a new glycosynthase derived from a lysozyme was developed by the CBO team in order to prepare long-chain chitin oligosaccharides with perfect control over their size and excellent yields. Click on the title for more information.
A New Route to NAG-NAM Disaccharide, an Important Building Block for Peptidoglycan Oligomer Synthesis.
The Chemistry and Biotechnology team of CERMAV has just published a very efficient methodological approach for the synthesis of the repeating unit of peptidoglycan, an essential constituent of the bacterial cell wall whose biosynthesis is targeted by most antibiotics.
This first result is the basis of a global strategy for accessing synthetic peptidoglycan oligomers, fundamental tools to decipher the life cycle of this complex polymer.
Click on the title for more information.
Kanhaya Lal thesis defense on December 15th , 2021
Kanhaya LAL is defending his thesis at CERMAV in the framework of the European project PhD4GlycoDrug, in co-tutorship with the University of Milan. It is entitled “Structure-based design of Glycomimetic ligands for the N-Terminal domain of BC2L-C Lectin”.
Antoine Rousseau thesis defense on December 16th , 2021
Antoine Rousseau completed his thesis at Cermav under the co-supervision of Sébastien Fort (CNRS Research Director) and Sylvie Armand (Lecturers at Université Grenoble Alpes). It is entitled “Peptidoglycan oligomers synthesis to study the bacterial cell wall metabolism”. Click on the title for more information.
Video : Hamed Ahmadi-Nohadi research work
Discover the manufacture of micro / nanofiber layers by the electrospinning method developed in Hamed Ahmadi-Nohadi’s thesis under the supervision of Issei Otsuka, thanks to funding from Labex Arcane.
Click on the title to access the video.
Dania Martínez-Alarcón thesis defense on September 17th, 2021
Dania Martínez-Alarcón completed her thesis within the framework of the European network PhD4GlycoDrug. It was co-directed by Annabelle Varrot (Director of Research CNRS, in our lab) and Roland Pieters (Utrecht University in the Netherlands). The subject of her thesis is the following : “Characterization of lectins from emergin fungi and identification from fungal extracts”. Click on the title for more information.
Maxime Leprince thesis defense on September 24th, 2021
Maxime Leprince completed his thesis in co-supervision between our laboratory (under the co-supervision of Prof. Rachel Auzély) and the CEA – Department of Biology and Health Technologies “DTBS”, Chemistry, Sensors and Biomaterials laboratory “L2CB” (under the co-supervision of Dr Isabelle Texier-Nogue). The subject of his thesis is the following “Design of polysaccharide-based conductive inks and hydrogels for the development of controllably biodegradable bioelectronics devices”. Click on the title to access the summary.
Wei Li thesis defense on July, 26th 2021
This thesis was completed in our laboratory, under the supervision of Dr. Yoshiharu NISHIYAMA. The subject is: “Preparation of cellulose oligomers by acid hydrolysis.” Click on the title for more information.
Computational Modeling in Glycoscience
Advancements in high-performance computing have allowed molecular simulation methods to play a more substantial role in supporting experiments and transcend such mandate to guide experimental design and lead autonomously scientific discovery. This review presents the foundations underlying the multiscale molecular simulations methods, from atomistic to coarse-grained, used in complex carbohydrate research. The applications to glycan and glycoconjugates, polysaccharides, proteins-glycans interactions,… illustrate the relevance of computer simulations to the field of glycoscience. Click on the title for more information.
Electrospun Cellulosic Membranes toward Efficient Chiral Resolutions via Enantioselective Permeation
Many biologically-active compounds, such as drugs, agrochemicals, food additives, etc. have chiral structures (like right- and left-hands) and their physiological properties usually depend on their chirality. In this study, cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC), known as one of the most versatile chiral selectors packed in columns for chiral chromatography, is electrospun for the first time to fabricate an enantioselective membrane toward efficient chiral
resolutions. We believe that such a novel electrospun cellulosic membrane having both the enantioselective permeation property and the capacity to be used in pressure-driven filtration processes is a significant step forward toward large-scale chiral resolutions. Click on the title for more information.
Electrospun Polysaccharidic Textiles for Biomedical Applications
We are publishing a new review on electrospun polysaccharide textiles for biomedical applications, in a new open access journal entitled Textiles, which covers studies in the field of textile science and industry. Click on the title for more information.
Proteome-wide prediction of bacterial carbohydrate-bindingproteins as a tool for understanding commensal and pathogencolonisation of the vaginal microbiome
Bacteria use carbohydrate binding proteins (CBP), such as lectins and carbohydrate binding modules (CBMs), to anchor themselves to specific sugars on host surfaces. This study provides new insight into the potential mechanisms of colonization by commensals and potential reproductive tract pathogens that underlie health and disease states. Click on the title for more information.
Juliette Francillon thesis defense on June 25th, 2021
Juliette Francillon completed her thesis in co-supervision between our laboratory, under the direction of Dr. Claire Boisset, and the laboratory
Papermaking Process Engineering Laboratory (LGP2) – UMR CNRS 5518 – Grenoble INP – Agefpi in Grenoble, under the direction of Prof. Christine Chirat.
Her thesis is entitled: “Study of the molecular diversity of soluble hemicellulose oligosaccharides derived from wood autohydrolysates.”
Rafael Bermeo thesis defense on June, 18th 2021
Rafael Bermeo will defend his thesis on June 18th, 2021, which he performed under the supervision of Dr. Annabelle Barrot (CNRS Research Director at Cermav – UPR5301) and which is entitled “Design, synthesis and evaluation of antagonists towards BC2L-C ”. Click on the title for more information.
Morphological and Structural Aspects of α-Glucan Particles from Electron Microscopy Observations
The book “Enzymology of Complex Alpha-Glucans”, edited by Felix Nitschke, will be published in July 2021. The first of the 11 chapters is devoted to the morphological and structural study of starch granules and glycogen using electron microscopy various techniques.
