UPR 5301

Maxime Leprince thesis defense on September 24th, 2021

Maxime Leprince completed his thesis in co-supervision between our laboratory (under the co-supervision of Prof. Rachel Auzély) and the CEA - Department of Biology and Health Technologies "DTBS", Chemistry, Sensors and Biomaterials laboratory "L2CB" (under the co-supervision of Dr Isabelle Texier-Nogue). The subject of his thesis is the following "Design of polysaccharide-based conductive inks and hydrogels for the development of controllably biodegradable bioelectronics devices". Click on the title to access the summary.


Research on flexible biocompatible conductive materials has been burgeoning over the last decades due to the huge number of applications in bioelectronics. Recently, conductive bioelectronic devices based on commercial PEDOT:PSS (3,4-poly(ethylenedioxythiophene) : poly(styrene sulfonate) have been developed, using conductive hydrogels as contact electrodes. The soft and flexible nature of these polymer networks make them suitable candidates for electronics/soft tissue interface. However, those conductive materials display some limitations for in vivo implantation due to problems of biocompatibility and biodegradability of PSS. In this work, we aimed to replace PSS by a modified hyaluronic acid (HA) derivative to develop a new biocompatible and degradable PEDOT dopant. This HA derivative enabled to design a new biocompatible, degradable, printable and cross-linkable PEDOT-based ink, and as well, served as an extracellular-matrix-mimicking building block for the construction of pure conductive hydrogels. These properties could enable the design of soft transient electronic devices, which could avoid implant removal surgery.”