Abstract:
“This thesis, carried out in collaboration between the Département de Chimie Moléculaire (DCM), and CEntre de Recherches sur les MAcromolécules Végétales (CERMAV) is dedicated to the development of new redox glyconanoparticles (GNPs). They are obtained by self-assembly of amphiphilic block copolymer systems using nanoprecipitaion technique: polystyrene-block-beta-cyclodextrin (PSCD) and polystyrene-block-maltoheptaose (PSMH) or a mixture of these 2 copolymers in different proportions. The morphology and the nanometric size of the GNPs were determined thanks to characterizations by dynamic light scattering, transmission and scanning electron microscopy. Depending on the nature of the chosen redox compound, the GNPs functionalization was carried out during their formation or after self-assembly using the inclusion properties of cyclodextrins. Another approach of the thesis is the study of the electrochemical properties of these redox glyconanoparticles in solution as well as their electrochemical transposition on carbon electrode. For a better understanding of the electrochemical properties of modified glyconanoparticles, a study of the electrochemical properties of redox compounds in solution, as for the viologen entity substituted by the adamantane or pyrene group, was carried out. A final aspect explored is the use of glyconanoparticles in bioelectrochemistry for the elaboration of enzymatic biocathodes and enzymatic glucose biosensors, this latter being chosen as proof of concept.”
Key words: electrochemistry, bioelectrochemistry, glyconanoparticles, block copolymer, cyclodextrin, maltoheptaose
