Size-controlled synthesis of beta(1–>4)-GlcNAc oligosaccharides using an endo-glycosynthase.
An enzymatic cascade using a new glycosynthase derived from a lysozyme was developed by the CBO team in order to prepare long-chain chitin oligosaccharides with perfect control over their size and excellent yields. Click on the title for more information.
A New Route to NAG-NAM Disaccharide, an Important Building Block for Peptidoglycan Oligomer Synthesis.
The Chemistry and Biotechnology team of CERMAV has just published a very efficient methodological approach for the synthesis of the repeating unit of peptidoglycan, an essential constituent of the bacterial cell wall whose biosynthesis is targeted by most antibiotics.
This first result is the basis of a global strategy for accessing synthetic peptidoglycan oligomers, fundamental tools to decipher the life cycle of this complex polymer.
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Kanhaya Lal thesis defense on December 15th , 2021
Kanhaya LAL is defending his thesis at CERMAV in the framework of the European project PhD4GlycoDrug, in co-tutorship with the University of Milan. It is entitled “Structure-based design of Glycomimetic ligands for the N-Terminal domain of BC2L-C Lectin”.
Antoine Rousseau thesis defense on December 16th , 2021
Antoine Rousseau completed his thesis at Cermav under the co-supervision of Sébastien Fort (CNRS Research Director) and Sylvie Armand (Lecturers at Université Grenoble Alpes). It is entitled “Peptidoglycan oligomers synthesis to study the bacterial cell wall metabolism”. Click on the title for more information.
