
Taking advantage of the specific properties of water-soluble natural polymers, we seek to develop new gelling agents, thickeners, complexing agents, dispersing agents or stabilizers for various uses (hydrogels as support for tissue regeneration, biocompatible injectable matrices, self-repairing materials, micro-and nanosystems for controlled drug release...). These polysaccharides can have an amphiphilic character, show capabilities of association, can bear various (bio)active hydrophilic / hydrophobic molecules, respond to environmental stimuli and/or form assemblies with inorganic nanomaterials...
The design of these macromolecular systems requires the use of a whole range of chromatographic techniques for the purification and structural characterization of oligo-and polysaccharides, as well as techniques for the characterization of macromolecules in solution (Size-Exclusion Chromatography, Rheology , NMR, Drop tensiometer). The synthesis of modified polysaccharides relies on methodologies taking into account the concepts of green chemistry.
1. Hydrogels: materiaux injectables ou supports solides à base d'acide hyaluronique et de dérivés de cellulose.
2. Microcapsules de chitosane/hyaluronane alkylé pour la vectorisation du taxol.
3. Nanoparticules thermosensibles obtenues à partir de conjugués hyaluronane-polymère.
4. "Chimie clic" - nanogels de polysaccharides