UPR 5301

bandeau cermav

Sébastien FORT

CNRS Senior Scientist
04 76 03 76 64

Scientific interests

My research aims at developing chemo-enzymatic methods to prepare oligosaccharides and glycoconjugates using in vitro biocatalysis, whole-cell biocatalysis and click chemistry. The target molecules are used as molecular probes to decipher biological processes and to bring solutions to societal need in human health and agriculture.

My ongoing projects focus on the production of :

  • Bacterial cell wall oligosaccharides to study and fight antimicrobial resistance
  • Cell-surface glycans and mimetics to prevent viral or bacterial infections
  • Signaling molecules in plant immunity and plant-microbial symbioses
  • Cross-linking probes to characterize receptors involved in inflammatory diseases
  • Glycosylated proteins of therapeutic or biocatalytic interest

Recent significant publications

  • Rousseau, A.; Michaud, J.; Pradeau, S.; Armand, S.; Cottaz, S.; Richard, E.; Fort, S. Hijacking the Peptidoglycan Recycling Pathway of Escherichia Coli to Produce Muropeptides. Chem. Eur. J. 2023, 29 (6).
  • Rivollier, P.; Samain, E.; Armand, S.; Jeacomine, I.; Richard, E.; Fort, S. Synthesis of Neuraminidase‐Resistant Sialyllactose Mimetics from N‐Acyl Mannosamines Using Metabolically Engineered Escherichia Coli. Chem. Eur. J. 2023, 29 (46).
  • Rousseau, A.; Armand, S.; Cottaz, S.; Fort, S. Size-Controlled Synthesis of β(1→4)-GlcNAc Oligosaccharides Using an Endo-Glycosynthase. Chem. Eur. J. 2021, 27 (70), 17637–17646.
  • Masselin, A.; Rousseau, A.; Pradeau, S.; Fort, L.; Gueret, R.; Buon, L.; Armand, S.; Cottaz, S.; Choisnard, L.; Fort, S. Optimizing Chitin Depolymerization by Lysozyme to Long-Chain Oligosaccharides. Mar. Drugs 2021, 19 (6), 320.
  • Masselin, A.; Petrelli, A.; Donzel, M.; Armand, S.; Cottaz, S.; Fort, S. Unprecedented Affinity Labeling of Carbohydrate-Binding Proteins with s-Triazinyl Glycosides. Bioconjug. Chem. 2019, 30 (9), 2332–2339.